Does anyone know if doxycycline is used to treat prostate cancer?

not to sure on this one but i searched the web and couldnt find anything out on there is doxycycline used to treat prostate cancer?

Does anyone know if doxycycline is used to treat prostate cancer?
Effects of doxycycline on human prostate cancer cells in vitro.Fife RS, Sledge GW Jr, Roth BJ, Proctor C.


Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.





Prostate cancer is the most common form of cancer in older


men and the major cause of death from prostate cancer is metastatic disease. The matrix metalloproteinases (MMPs) play a significant role in the growth, invasion and metastasis of many tumors, including those of the prostate. We previously demonstrated that doxycycline, a synthetic tetracycline, inhibits MMPs and cell proliferation and induces apoptosis in several cancer cell lines. We also demonstrated that in an in vivo model of metastatic breast cancer in athymic mice doxycycline inhibits tumor size and regrowth after resection. In the present study, gelatinolytic activity in the human prostate cancer cell line, LNCaP, was suppressed and significant inhibition of cell growth occurred after exposure to 5 or 10 microg/ml of doxycycline, while cell growth was normal in untreated cells. Radioisotope incorporation into proteins was reduced by doxycycline. DNA fragmentation, consistent with apoptosis, was demonstrated in cells treated with doxycycline. These data suggest that doxycycline may have potential utility in the management of prostate cancer.





PMID: 9619856 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/query...





So, treatment no, but as was stated above...................


These data suggest that doxycycline may have potential utility in the management of prostate cancer.
Reply:Doxycycline is used to treat bacterial infections, including pneumonia and other respiratory tract infections; Lyme disease; acne; infections of skin, genital, and urinary systems; and anthrax (after inhalational exposure). It is also used to prevent malaria. Doxycycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics will not work for colds, flu, or other viral infections.
Reply:There is no current evidence outside of laboratory studies and clinical trials that doxycycline is useful in the treatment of prostate cancer. It is an antibiotic, and as such, could possibly be used to treat infections of the prostate. More standard treatments of prostate cancer include surgery or radiation, hormone therapy, and chemotherapy.